MRC Senior Clinical Fellow | Honorary Consultant Neurologist
- Head, Oxford Autoimmune Neurology Group
- MRC Senior Clinical Fellow
- Honorary Consultant Neurologist
- Senior Fellow, Oxford BRC
- Associate Editor @Brain
Autoantibody-mediated neurological diseases
I am a consultant neurologist and clinician-scientist with clinical and laboratory experiences in the field of autoantibody mediated diseases of the nervous system, in particular the central nervous system. I care for patients with these disorders and run a research group to learn more about the origins and treatments of these diseases. I welcome referrals of patients with possible autoimmune neurological conditions.
I have studied the antigenic targets of autoantibodies in patients with encephalitis and epilepsies. In particular, my research has focused on LGI1, CASPR2 and the NMDA-receptor. In addition, I have been involved with projects examining autoantibodies against the GABAA-receptor, glycine receptors and aquaporin-4.
Along with colleagues, I have looked after and met multiple patients with these disorders, phenotypes >150 patients in great detail, and characterised their clinical responses to therapies. These findings have generated, often distinctive, clinical features which correlate well with a high likelihood of an immunotherapy-responsive condition. They have also identified novel clinical descriptions of patients with cognitive, movement and seizure disorders, in particular faciobrachial dystonic seizures - a novel autoimmune epilepsy syndrome which often responds better to immunotherapies than conventional anti-epileptic drugs.
I run a research group combining ~15 talented clinicians, clinician-scientists and basic scientists with the aim of better understanding the causes and potential treatments of this condition. In particular, we study the role of B cell subsets in propagating autoantibody responses. We are funded by the Wellcome Trust, Medical Research Council, British Medical Association, Association of British Neurologists and industry partners.