Colleges
Websites
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Institute of Developmental & Regenerative Medicine
IDRM is a unique flagship institute at the University of Oxford combining insights into organ development and regeneration to treat birth defects and acquired disease
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British Heart Foundation
BHF Professor of Regenerative Medicine
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Foundation Leducq
Programming the Failing Heart to a Regenerative State
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Publications
Link to PubMed
Paul Riley
PhD, BSc
BHF Professor of Regenerative Medicine & Chair of Development and Cell Biology
Paul Riley took up the Chair of Development and Cell Biology in the Department of Physiology, Anatomy and Genetics on 1st October 2011, having been awarded a British Heart Foundation Personal Chair of Regenerative Medicine to support this position. He is also director of a recently established BHF Oxbridge Centre for Regenerative Medicine. He was previously Professor of Molecular Cardiology at the UCL-Institute of Child Health, London, where he was a principal investigator within the Molecular Medicine Unit at UCL-ICH since 1999. Prior to this, he obtained his PhD at UCL (1992-1995) and completed post-doctoral fellowships at the Samuel Lunenfeld Research Institute, Toronto, Canada and the Weatherall Institute of Molecular Medicine, Oxford (1996-1999). In 2008, Professor Riley was awarded the Outstanding Achievement Award of the European Society of Cardiology (ESC) Council on Basic Sciences. The award recognises a landmark discovery in the field of basic cardiovascular science when his team found that Thymosin b4 could mobilise dormant cells from adult epicardium to form new blood vessels in the heart, a major step towards finding a DIY mechanism to repair injury following a heart attack. Currently Professor Riley's team are focusing on exploiting the full potential of activated epicardial cells towards regenerating adult heart and understanding the mechanisms of activation of this lineage to extrapolate to human patients suffering from cardiovascular disease.
Key publications
Cardiac lymphatics are heterogeneous in origin and respond to injury
Journal article
Klotz L. et al, (2015), Nature, 522, 62 - 67
Dynamic haematopoietic cell contribution to the developing and adult epicardium
Journal article
Balmer GM. et al, (2014), Nature Communications, 5
Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing
Journal article
Evans MA. et al, (2013), Nature Communications, 4
Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3
Journal article
Risebro CA. et al, (2012), Circulation Research, 111
De novo cardiomyocytes from within the activated adult heart after injury
Journal article
Smart N. et al, (2011), Nature, 474, 640 - 644
Recent publications
Organ-specific fibroblast dynamics revealed via an integrated experimental-computational framework
Preprint
Stewart CL. et al, (2026)
Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens
Journal article
Aguado-Alvaro LP. et al, (2025), Nature Communications, 16
Type V collagen from macrophages regulates initial collagen assembly and alignment in post-infarcted hearts
Journal article
Sun X. et al, (2025), Npj Regenerative Medicine, 10
Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration.
Journal article
Gamen E. et al, (2025), Elife, 14
Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration
Journal article
Gamen E. et al, (2025), eLife, 14
