Molecular interactions of leukoctye surface receptors
We study how immune regulation depends on molecular interactions of leukocyte surface receptors. The overall effect of a receptor can vary from activation to inhibition. It is critical to understand how this is controlled to interpret the role of a receptor in a complex biological system and for designing therapeutic intervention in autoimmune diseases and cancer. By studying selected receptors, we aim to identify both the specific niche the receptors occupy and the general paradigms.