Katharine Owen

Associate Professor of Diabetes

NIHR Clinician Scientist
Honorary Consultant Physician

Genetics of Type 2 Diabetes & Monogenic Diabetes

Diabetes arising in young adults has a wide range of underlying aetiologies. This includes genetic causes of beta-cell dysfunction (Maturity-onset diabetes of the young, MODY). We are investigating the characteristics of different subtypes of MODY and how to identify them from those with commoner causes of diabetes. Our research programme aims to implement systematic diagnostics for aetiology of diabetes into routine clinical care. At the moment we are investigating whether there are specific non-genetic biomarkers for MODY subtypes and have recently discovered that low levels of highly-sensitive C-reactive protein are a marker for HNF1A mutations.

Recent publications

Transdermal Blood Sampling for C-Peptide Is a Minimally Invasive, Reliable Alternative to Venous Sampling in Children and Adults With Type 1 Diabetes

Besser REJ. et al, (2024), Diabetes Care, 47, 239 - 245

Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

Tobias DK. et al, (2023), Nature Medicine, 29, 2438 - 2457

Interlaboratory evaluation of plasma N-glycan antennary fucosylation as a clinical biomarker for HNF1A-MODY using liquid chromatography methods

Demus D. et al, (2021), Glycoconjugate Journal, 38, 375 - 386

Diabetes in pregnancy: time to focus on women with type 2 diabetes

Hirst JE. et al, (2021), The Lancet Diabetes and Endocrinology, 9, 332 - 333

The correlation between breath acetone and blood betahydroxybutyrate in individuals with type 1 diabetes

Hancock G. et al, (2021), Journal of Breath Research, 15

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