Contact information
Websites
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Sir William Dunn School of Pathology
Department website
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Personal Website
Department website
David Vaux
Molecular pathology of post-translational modification
The group is interested in the molecular mechanisms by which pathological perturbations in the post-translational modifications of proteins (including proteolytic maturation, oligomeric assembly, ubiquitination, phosphorylation and fatty acyl modification) can lead to severe human disease. Conditions resulting from defective or altered post-translational modification are extremely diverse, ranging from Alzheimer’s disease, Type II diabetes, neural tube defects, lipodystrophy and cardiomyopathy, to tumour metastasis and premature ageing syndromes.