David Vaux

Molecular pathology of post-translational modification

The group is interested in the molecular mechanisms by which pathological perturbations in the post-translational modifications of proteins (including proteolytic maturation, oligomeric assembly, ubiquitination, phosphorylation and fatty acyl modification) can lead to severe human disease. Conditions resulting from defective or altered post-translational modification are extremely diverse, ranging from Alzheimer’s disease, Type II diabetes, neural tube defects, lipodystrophy and cardiomyopathy, to tumour metastasis and premature ageing syndromes.