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Further information

Anna L Gloyn

The genetics and functional biology of Type-2 diabetes & related traits

Anna’s research is focused on using naturally occurring mutations in humans as tools to identity critical regulatory pathways and insights into normal physiology. Anna’s early post-doctoral research led to the identification a new genetic aetiology for permanent and transient neonatal diabetes due to KCNJ11 mutations and resulted in one of the first examples of the determination of the molecular genetic aetiology leading to improved treatment options for patients (Gloyn et al New England Journal of Medicine 2004).  Recently the Gloyn group have reported a novel genetic cause of constitutive insulin sensitivity in humans due to mutations in the PTEN gene (Pal et al New England Journal of Medicine 2012).

Current research projects are focused on the translation of association signals for type 2 diabetes and glycaemic traits into molecular, cellular and physiological mechanisms and clinically useful tools. Anna is an active member of several international consortia, including DIAGRAM (Diabetes Genetics Replication and Meta-analysis), MAGIC (Meta-analysis of Glucose and Insulin traits Consortium) and the Genetics of Type 2 Diabetes (GoT2D).

Anna’s work has been recognized both nationally and internationally as she is a recipient of a Diabetes UK RD Lawrence research fellowship (2003), a European Association for the Study of Diabetes Rising Star Award (2005), a Medical Research Council New Investigator Award (2007), the RD Lawrence Named Lecturer (Diabetes UK Annual Professional Conference 2009) and most recently a Wellcome Trust Senior Fellowship in Basic Biomedical Research (2011).