KTRR/ARUK Research Fellow
I was an undergraduate student of Physiology at Cardiff. I received my PhD from St Georges University Medical School in 2009, where I worked on the mechanobiology of the synovial joint under Professor J.R Levick. From 2009 until 2014 I worked with Professor Martin Knight in a bioengineering group at Queen Mary University of London, studying the role of the primary cilium in a range of contexts but primarily the cellular response to mechanical cues.
During the latter part of my time at Queen Mary I began to study how the cilium is altered by and regulates the cellular response to inflammatory cytokines. I am now keen to understand how this role is important in disease pathogenesis and whether we can learn enough about ciliary regulation of signalling as such to exploit this contexts where signalling is ‘miss-tuned’. This involves working from the molecular level, including high resolution microscopy, all the way through to models of human disease. I’m keen to understand how ciliary regulation of signalling affects homeostasis and the workings of the adult body as well as the cell. I’m very keen to employ microscopy to answer these questions but also translate the work up to physiology and pathology.
I’m a new principal investigator in the Kennedy Institute of Rheumatology at Oxford. I have a Kennedy fellowship within the ARUK Centre for Osteoarthritis Pathogenesis, which is enabling the translation of cilia biology to disease.