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The inexorable rise of antibiotic resistant bacteria threatens to cast our society back to the days before Alexander Fleming's discovery of penicillin.

Some of the most problematic of these multidrug resistant microbes are Gram-negative bacteria which, because of their additional outer membrane, are not susceptible to antibiotics that are active against Gram-positive bacteria.The Wellcome Trust has recently funded a collaborative award for the development of a new class of antibiotics, based on proteins that specifically kill Gram-negative bacteria. Spearheaded by Colin Kleanthous in Oxford and Dan Walker in Glasgow, and including colleagues in Oxford, Glasgow, London and the Sanger Institute in Cambridge, the new funding will focus on protein toxins known as bacteriocins.

Read more (Department of Biochemistry website)