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Think 'Typhoid' and you may picture 19th century slums, but the killer disease, while now vanishingly rare in the developed world, still kills more than 200,000 people each year. That's why Oxford University scientists are asking for volunteers to help test a possible new vaccine for the disease.

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Typhoid fever is caused by the bacteria Salmonella Typhi, related to but very different from the Salmonella that causes food poisoning. Salmonella Typhi is mainly found in developing nations, causing illness in 22 million people each year, most commonly in poorer communities with inadequate clean water and sewage disposal facilities.

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