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New findings that shed light on how epigenetic components in mammals shape transcription have been published by the Klose group in the Department of Biochemistry.

 

Figure 1. Schematic showing that the chromatin-modifying complex SET1 is targeted to active genes at CpG islands via its component CFP1

Schematic showing that the chromatin-modifying complex SET1 is targeted to active genes at CpG islands via its component CFP1

The Cell Reports paper, a collaborative effort between labs in Oxford, Japan and the USA, reveals how a key histone-modifying enzyme is targeted to promoters and helps ensure appropriate gene expression (1). The findings provide an important step towards understanding how an epigenetic change can influence transcription.

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