Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

An international research collaboration led by researchers from the Universities of Helsinki and Oxford has identified the biological mechanism through which a genetic variant protects against type 2 diabetes.

Study decodes gene function that protects against type 2 diabetes

The study, published in the journal Nature Genetics, finds that changes in a gene which makes zinc transporter proteins reduce the risk of type 2 diabetes by enhancing insulin secretion from the pancreas.

Type 2 diabetes affects almost 400 million people across the world. It is caused by a combination of lifestyle as well as genetic factors which together result in high blood sugar levels.

One such genetic factor is a variation in a gene called SLC30A8, which encodes a protein which carries zinc. This protein is important, because zinc is essential for ensuring that insulin, (the only hormone that can reduce blood sugar levels) has the right shape in the beta-cells of the pancreas.

Read more (Radcliffe Department of Medicine website)

Similar stories

New therapeutic targets identified in the treatment of psoriatic arthritis

Researchers identify two inflammatory-driving proteins, osteopontin and CCL2, highly expressed in psoriatic arthritis joints.

Treatment choice for rotator cuff disorders could create efficiency and savings for the NHS

A trial that evaluated the clinical and cost effectiveness of physiotherapy treatments for rotator cuff disorders suggests cost savings can be made while maintaining positive patient outcomes.

Neutrophil molecular wiring revealed: transcriptional blueprint of short-lived cells

Researchers publish the first blueprint of transcriptional factors that control neutrophil-driven inflammation in Nature Immunology.

Daily contact COVID-19 testing for students effective at controlling transmission in schools

A study by the University of Oxford has found that daily testing of secondary school students who were in contact with someone with COVID-19 was just as effective in controlling school transmission as the current 10-day contact isolation policy.