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Single human cells reveal molecular mechanisms in cell cycle control

Research

A new paper scrutinizing how mammalian cells control transition into the DNA replication phase of the cell cycle comes out in Cell Systems.

The research is part of an ongoing collaboration between the labs of Bela Novak in the Department and Chris Bakal at the Institute of Cancer Research, London. Postdocs Alexis Barr at the ICR and Stefan Heldt in Oxford are responsible for much of the work. It provides a molecular explanation for how mammalian cells transition abruptly and irreversibly into the DNA replication phase. The work also provides insight into how other transitions in the cell cycle may be controlled.

Read more (Department of Biochemistry website)

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