New research from a randomised clinical trial provides the strongest long-term evidence yet comparing partial (PKR) and total (TKR) knee replacements for patients with osteoarthritis. Published in The Lancet Rheumatology, the study shows both PKR and TKR being equally effective and offering similar clinical outcomes.
Professor Tim Elliott and colleagues from Oxford Cancer and the Centre for Immuno-Oncology welcomed the Brazilian Minister of Health and senior officials for an official visit organised by the British Embassy in Brazil. The delegation met to exchange insights on cancer research, regulation, and public health, with discussions focusing on prevention, early diagnosis, and innovative treatments such as mRNA vaccines and immunotherapy.
A new international study co-led by Professor Arri Coomarasamy of the University of Birmingham and the Nuffield Department of Women\u2019s and Reproductive Health, University of Oxford, has shown that diagnosing postpartum haemorrhage (PPH) within the first 90 minutes after childbirth can be crucial in preventing maternal deaths.
Two Oxford University academics are to co-lead ambitious new research projects backed by\u202fEuropean Research Council (ERC) Synergy Grants, part of the EU\u2019s Horizon Europe research and innovation programme. Synergy Grants foster collaboration between outstanding researchers, enabling them to combine their expertise, knowledge and resources to push the boundaries of scientific discovery.
People at high risk of lung cancer will soon be able to receive the first-ever experimental vaccine, 'LungVax', designed to prevent the disease, in a world-first clinical trial. The LungVax vaccine carries a series of genetic instructions which train the immune system to recognise tumour antigens on the surface of abnormal lung cells.
A new study led by researchers at the MRC Molecular Haematology Unit has shown that resistance to a targeted treatment for acute myeloid leukaemia (AML) can develop much earlier than expected.
Researchers at the Kennedy Institute have provided the most comprehensive overview to date of how the distinctive segmented nucleus of neutrophils influences their function in health and disease.
Leading researchers from the Nuffield Department of Primary Care Health Sciences and Nuffield Department of Population Health came together this week for a special event highlighting the enduring impact of research into tobacco addiction and public health.
The Teaching Excellence Awards recognise and reward excellence in teaching, supervision, the organisation and development of teaching, and support for teaching and learning, within a research-intensive environment.
Ovarian cancer remains a devastating global health challenge: each year, over 300,000 women are diagnosed, and nearly 200,000 lives are lost, largely because the disease is detected at a late stage. Women carrying inherited genetic changes face a significantly elevated lifetime risk, over 40%, and current preventive strategies often require invasive surgery that compromises fertility. These limitations underscore an urgent need for non-surgical preventive options, and vaccines could offer a groundbreaking solution.
New research shows that iron from supplements and fortified foods is well-absorbed in children living with virally suppressed HIV, and that administering iron supplements with prebiotics may enhance their effectiveness and improve their safety.
Researchers at the MRC Translational Immune Discovery Unit have identified how rare populations of abnormal cells drive the formation and persistence of fistulas - painful, tunnel-like tracts that develop in around 30% of people with Crohn\u2019s disease - paving the way for targeted treatments.
A new study published in Nature Communications reveals how the hippocampus \u2014 a brain region crucial for memory and navigation \u2014 supports flexible learning when sensory information is uncertain or incomplete.
Oxford scientists are part of a new \u00a315.9 million UK initiative to transform disease research through the development of advanced human tissue models. The INTREPID project will evaluate and optimise the use of live human tumour samples to enhance the accuracy of preclinical research, speed up drug discovery, and reduce dependence on animal testing.
It found that shame partially explained the relationship between hairpulling and depression, and fully explained the relationship between hairpulling and anxiety.
A new study led by researchers at Oxford Population Health has found that sodium-glucose co-transporter-2 (SGLT2) inhibitors provide major kidney and heart benefits for people with chronic kidney disease (CKD), regardless of whether they have diabetes or raised levels of albumin in their urine.
Professor Ellie Tzima has been awarded a highly competitive European Research Council (ERC) Synergy Grant to investigate the enigmatic neurovascular interface of peripheral nerves \u2013 a critical but poorly understood junction between the nervous and vascular systems.
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