Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Dr Anne Kiltie and her team of scientists in the Department of Oncology are trying to give patients with bladder cancer the information they need to choose between radiotherapy and surgery.

Virtually every cell in the tumour contains a protein called MRE11, but some tumours contain more of this protein than others.  MRE11 is involved in detecting damage to DNA; the same damage caused by radiotherapy, so being able to tell whether different amounts of MRE11 is important for whether radiotherapy works is the next step in this project.

Anne and her group have developed a simple way of detecting the amount of this protein that each cell contains. We could, therefore, test a patient and tell them something about their tumour and how well radiotherapy would work, although we can’t do this until we’re sure that this will be reliable information.

Read more

Similar stories

Professor Sir Andrew Pollard Awarded the James Spence Medal in 2022

Professor Sir Andrew Pollard, BSc MA MBBS MRCP(UK) FRCPCH PhD DIC FHEA FIDSA FMedSci, is Professor of Paediatric Infection and Immunity at the University of Oxford, Honorary Consultant Paediatrician at Oxford Children’s Hospital and Vice Master of St Cross College, Oxford.

COVID-19 vaccine protects people of all body weights from hospitalisation and death, a study of 9 million adults in England finds

Two doses of the COVID-19 vaccine are effective against severe disease for people who are underweight, overweight, or who have obesity, finds new research published in The Lancet Diabetes and Endocrinology, led by researchers at the University of Oxford.

New study finds that politicians typically enjoy longer lives than general populations

New data show politicians have a considerable survival advantage over general populations, based on information from 11 countries and over 57,500 politicians. In some countries this survival advantage is at the highest level for 150 years, and life expectancy at age 45 was found to be around seven years higher for politicians compared to general populations in certain countries.

Five ways the pandemic has affected routine medical care

Since the beginning of the pandemic, COVID has infected at least a third of the UK population and is estimated to have factored in the deaths of almost 200,000 people in the UK. But critically, COVID has also had a devastating impact on our healthcare systems. While this was expected, new evidence is beginning to reveal the scope of the issue – in particular the effects for people living with long-term health conditions.

Clinical trials for a malaria vaccine start in Mali and Indonesia

Sanaria Inc. announced that two new Phase 2 trials of its pioneering malaria vaccines have started. The first is in 6- to 10-year-old children living in Bancoumana, Mali, a malarious region of West Africa. The second is in Indonesian soldiers based in Sumatra, Indonesia. The soldiers will be deploying for six to nine months this coming August to an intensely malarious district in eastern Indonesia.

Researchers discover novel form of adaptation in the auditory system

Researchers in the Department of Physiology, Anatomy and Genetics (DPAG) have found that the auditory system adapts to the changing acoustics of reverberant environments by temporally shifting the inhibitory tuning of cortical neurons to remove reverberation.