Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A new approach to targeting key cancer-linked proteins, thought to be ‘undruggable’, has been discovered through an alliance between industry and academia.

Image courtesy of Shutterstock

The study published in Nature shows that two novel and specific small-molecule inhibitors developed by the research teams can bind to and deactivate an enzyme that controls the stability of the p53 tumour suppressor protein. This deactivation allows p53 to be turned on, putting the brakes on cancer growth.

The majority of cancers have a faulty or inactive p53 which allows them grow out of control. But despite its important role in cancer, attempts to target p53 directly have hit a number of dead ends. To get around this problem the researchers in this alliance looked at a specialised system, the ubiquitin-proteasome system, which regulates the turnover of a range of proteins, including p53.

Read more (University of Oxford website)

Similar stories

No limit to the benefits of exercise in reducing the risk of cardiovascular disease

General Research

A new study led by the University of Oxford on over 90,000 participants shows that there is no upper threshold to the benefits of exercise in reducing the risk of cardiovascular disease – ‘every move counts towards better cardiovascular health.’

Accurate predictions of ovarian cancer outcome possible with new classification system

General Research

The new, Oxford-developed method for subtyping ovarian cancer has been validated in a recent collaboration between the University of Oxford and Imperial College London. Dubbed the ‘Oxford Classic’, researchers have demonstrated that it enables the accurate prediction of patient disease outcome, as well as the development of new targeted cancer therapies.

Accidental awareness in obstetric surgery under general anaesthesia more frequent than expected

General Research

The largest ever study of awareness during obstetric general anaesthesia shows around 1 in 250 women may be affected, and some may experience long-term psychological harm.