Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A research team led by Prof Alison Simmons at MRC Human Immunology Unit used single-cell technology to identify new players in the gut epithelial barrier.

Inflammatory Bowel Disease (IBD) is a disease that affects at least 300,000 people in the UK alone. Its incidence is increasing worldwide, in particular in industrial-urbanised societies. There is no cure for IBD, and while many patients can manage the symptoms with appropriate care, approximately 40% of patients do not respond to available therapies.

Diseases such as IBD develop when the symbiotic relationship between the cells lining the surface of the gut wall and the trillions of bacteria that live inside the gut lumen breaks down. Normally these bacteria are beneficial to our bodies, helping to digest food, training the immune system or preventing harmful bacteria from taking hold. However, in diseases such as IBD, the barrier cell layer that keeps these microorganisms inside the gut lumen breaks down, leading to emergence of harmful bacteria and subsequent inflammation.

Read more (MRC Weatherall Institute of Molecular Medicine website)

Similar stories

Urgent need for COVID-19 vaccine equity: UN-Oxford research

COVID-19 vaccine programmes are expected to cost poorer countries an additional 56.6% on health budgets, compared with just 0.8% on wealthy countries’ health expenditure, according to new data from the United Nations Development Programme (UNDP), the World Health Organisation (WHO) and the University of Oxford.

Difficulty hearing speech could be a risk factor for dementia

A new study led by University of Oxford researchers on over 82,000 participants has shown that difficulty hearing spoken conversations is associated with up to 91% increased risk of dementia.

Red and processed meat linked to increased risk of heart disease, Oxford study shows

Largest review of all large-scale studies to date finds red and processed meat increase the risk of heart disease.

How did people in Europe and SE Asia experience the first COVID-19 wave?

An international team, led by Phaik Yeong Cheah, conducted an anonymous online survey from May-June 2020, asking 5,058 people in Thailand, Malaysia, United Kingdom, Italy and Slovenia to share their experiences. Anne Osterrieder and colleagues in the Centre for Tropical Medicine & Global Health (Nuffield Department of Medicine) report the unequal impacts of public health measures, and the prevalence of ‘fake news’.