Colin Kleanthous in the Department of Biochemistry, in collaboration with Jennifer Potts at the University of York and colleagues in Oxford, have elucidated the structure and dynamic behaviour of a key protein in a stress-response pathway, revealing a new way in which stress sensors in general may function. Their work has been published in Nature Communications (The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core. Rajasekar KV, Zdanowski K, Yan J, Hopper JTS, Francis M-LR, Seepersad C, Sharp C, Pecqueur L, Werner JM, Robinson CV, Mohammed S, Potts JR and Kleanthous C. (2016) Nat. Commun. 7:12194 doi:10.1038/ncomms12194).
Read more (Department of Biochemistry website)