The potential of 'big data' to revolutionise health research and offer patients better, safer and more personalised treatments will be a major focus of the centre, which will be unique worldwide in providing a dedicated centre of excellence in the emerging field of big data in medicine.
The new Li Ka Shing Centre is being developed in two phases. The first phase will use high-throughput biology to define better drug targets in collaboration with industry, addressing a critical 'blockage' in the existing drug development process. The second phase will focus on the analysis of large data sets, bringing together leading researchers from across genetics, epidemiology and public health, clinical medicine, computer science and IT, statistics and bioinformatics.
The Prime Minister said:
"I am delighted to be backing our medical science sector and supporting the Li Ka Shing Centre for Health Information and Discovery, which has the potential to revolutionise medical research and healthcare in this country and beyond.
"The Li Ka Shing Centre for Health Information and Discovery will pioneer new advances in the analysis of medical data which can help scientists to better understand human disease and its treatment. “This will help to further develop a strong and competitive science and research base in this country which is vital for the UK to compete and thrive in the global race."
Sir Ka-shing Li said:
"What will happen here is more than the promise of harnessing the power of a data-intensive revolution to improve health care. The work of this centre will identify innovative ways to increase access to health care while lessening the burden of cost. It will free up resources for much needed investments in educational opportunities. And it will lead to new and deeper competencies that are pragmatic – precise solutions to sustain hope and stability today and lead to even greater discoveries tomorrow."
The Vice-Chancellor of Oxford University, Professor Andrew Hamilton, said:
"Big data will transform the way we treat patients and understand disease in the coming decades. We are collecting much of this data already. We owe it to ourselves to make full use of it and deliver more effective treatments for all of us as patients. The Li Ka Shing Centre, and this enormously generous gift which underpins it, along with continued public investment, will be instrumental in driving this research forward."
The two elements of the Li Ka Shing Centre for Health Information and Discovery
The two Institutes together form the Li Ka Shing Centre for Health Information and Discovery, which has been boosted by the £20m gift from the Li Ka Shing Foundation, in particular through funding new research positions. The £10m announced today from HEFCE through the second round of its Research Partnership Investment Fund (RPIF) is for the new Big Data Institute building. The Target Discovery Institute received £10m in the first RPIF round.
The Li Ka Shing Centre, through the Big Data Institute, will develop approaches for generating, storing and analysing large datasets in medical science for a better understanding of human disease and its treatment.
In modern society, very large sets of medical data are now routinely collected – through electronic patient records, DNA sequencing, comprehensive biological data on disease mechanisms, treatment monitoring, clinical trials, pharmacy records, medical imaging, and national registries of hospitalisations, cancers and other outcomes.
Bringing health-related datasets together for researchers to use in an anonymised way, and making use of new tools to scrutinise that data to gain insights, will provide powerful new insights into who develops illnesses and why.
Storing and analysing such vast quantities of data is not straightforward. Making sense of large amounts of complex data, making the right comparisons to generate robust and useful answers, and ensuring the security of the data needs to protect personal privacy are all important challenges.
These research opportunities and challenges will be at the core of the new Big Data Institute. Oxford University already has world-leading expertise in this area: pioneering the introduction of genomics into medical care, leading giant cohort studies like the Million Women Study and UK Biobank, running some of the largest clinical trials of treatment worldwide, and establishing methods for global disease surveillance in malaria and other major infectious diseases.
Drug target discovery
The Li Ka Shing Centre, through the Target Discovery Institute, will use high-throughput and automated approaches to speed the early stages of drug discovery, by identifying better targets for drug development in important diseases such as cancer, diabetes, dementia, psychiatric conditions and inflammatory diseases.
High-throughput biology brings automation to cell biology so that work that might once have been done by a lab technician with a pipette can be done on a large, high-speed scale. It is capable of generating very large amounts of data and provides the opportunity to systematically analyse biological pathways to understand, at a fundamental level, how these pathways could be manipulated to treat disease.
The pharmaceutical industry is hampered by companies' inability to embark on such extensive and detailed studied of potential targets. This can lead to companies spending literally billions of dollars identifying and developing drugs that are actually not acting on a promising biological pathway – slowing down the process of drugs being available for human health. The work at Oxford sees academia stepping in to fill that critical gap.
See background information on Oxford research in big data and drug discovery : http://www.ox.ac.uk/media/news_releases_for_journalists/130503.html