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Non-coding DNA could hold the key to an effective treatment for inflammatory diseases

Research

The non-coding regions of our DNA may play a crucial role in how our genes are expressed in inflammatory diseases, such as ankylosing spondylitis (AS). Yet, very little is known about these genetic associations.

Photo of Dr Amity Roberts and Dr Matteo Vecellio
Photo of Dr Amity Roberts and Dr Matteo Vecellio

NDORMS researchers Dr Amity Roberts and Dr Matteo Vecellio are working to change our knowledge of the genetic landscape in AS with an eye on its potential for generating new ideas about treating this condition.

AS is found to be associated with more than 60 genes; getting to grips with the mechanisms behind these genetic associations is no easy task and the pair has already received a European League Against Rheumatism (EULAR) Abstract Award 2016 in Basic Science in recognition of their work, presented at this year's EULAR Congress in London.

Read more (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences website)