Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Ludwig Oxford researchers have developed a method to improve mapping of chemical, or “epigenetic”, modifications to DNA that alter gene expression and play a big role in both healthy biology and cancer

© Shutterstock

Ludwig Cancer Research scientists report in the current issue of Nature Biotechnology a new and improved method to detect chemical modifications to DNA. These modifications—or “epigenetic” marks—help control gene expression and their aberrant distribution across the genome contributes to cancer progression and resistance to therapy.

Led by Chunxiao Song and Benjamin Schuster-Boeckler, both assistant members of the Ludwig Institute for Cancer Research, Oxford, the study demonstrates that their method, dubbed TET-assisted pyridine borane sequencing, or TAPS, is a less damaging and more efficient replacement for bisulfite sequencing, the current gold standard for mapping epigenetic modifications to DNA.

Read more (Ludwig Institute for Cancer Research website)