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A new study, published this week in eLife, found that Plasmodium falciparum kelch13 mutations that cause artemisinin resistant malaria in Southeast Asia show markedly different patterns of evolutionary selection in Africa.

The efficacy of Artemisinin Combination Therapy (ACTs), the current frontline treatment for falciparum malaria, is threatened by artemisinin resistance, which has been reported in several countries in Southeast Asia. To date, there are no clinical signs of artemisinin resistance in Africa, where malaria transmission is highest.

Read more (The Wellcome Trust Centre for Human Genetics website)