Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Research from Department of Physiology, Anatomy & Genetics provides new evidence that some cases of Congenital Heart Defect (CHD) may be caused by a combination of genetic and environmental factors.

Doctor examining a baby with stethoscope in clinic © Shutterstock

Congenital heart disease is a heart defect that a baby is born with. It is the most common type of birth defect, affecting 1 in 100 babies worldwide, with about 12 affected babies born each day in the UK. Untreated, more than half of these will die. Such defects occur because something goes wrong as the baby’s heart forms in the womb. This can be because of faulty genes inherited from the parents, or it can be caused by environmental factors affecting the mother during pregnancy.

Most research in this area over the past 20 years has focused on understanding the genetic causes of CHD. However, even though the latest genome sequencing technologies have identified mutations in over 100 genes that can cause CHD, still only 20-30% of cases can be explained genetics alone.

Read more (Department of Physiology, Anatomy & Genetics website)

Similar stories

Research programme tackling COVID-19 variants of concern receives funding boost

A gift from the Red Avenue Foundation will enable the expansion of a major research programme aimed at rapidly identifying and interrogating emerging COVID-19 variants.

Phase I trial begins of new vaccine against the Plague

Researchers at the University of Oxford today launched a Phase 1 trial to test a new vaccine against plague.

New therapeutic targets identified in the treatment of psoriatic arthritis

Researchers identify two inflammatory-driving proteins, osteopontin and CCL2, highly expressed in psoriatic arthritis joints.

Treatment choice for rotator cuff disorders could create efficiency and savings for the NHS

A trial that evaluated the clinical and cost effectiveness of physiotherapy treatments for rotator cuff disorders suggests cost savings can be made while maintaining positive patient outcomes.

Neutrophil molecular wiring revealed: transcriptional blueprint of short-lived cells

Researchers publish the first blueprint of transcriptional factors that control neutrophil-driven inflammation in Nature Immunology.

Daily contact COVID-19 testing for students effective at controlling transmission in schools

A study by the University of Oxford has found that daily testing of secondary school students who were in contact with someone with COVID-19 was just as effective in controlling school transmission as the current 10-day contact isolation policy.