Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Research from Department of Physiology, Anatomy & Genetics sheds light on a vicious cycle that causes specialised pancreatic cells to fail in their function to maintain healthy bloody sugar levels.

The pancreas produces the hormone insulin which is secreted from specialised cells called Beta cells (β-cells) into the bloodstream in response to a rise in circulating glucose. Insulin facilitates sugar absorption from the blood into other tissues, such as the heart, muscle and fat, where it is metabolised to create energy. This process is crucial in order to regulate the body’s blood sugar level and avoid hyperglycaemia, which means there is too much glucose in the blood.

Type 2 diabetes (T2D) now affects more than 450 million people worldwide. The socioeconomic burden of the disease is substantial because it markedly increases mortality, morbidity and health care costs. T2D arises when β-cells fail to secrete adequate amounts of insulin in order to maintain blood sugar levels within a normal, healthy range. The underlying mechanism behind why this happens is not well understood.

Read more (Department of Physiology, Anatomy & Genetics)

Similar stories

New reporting guidelines developed to improve AI in healthcare settings

New reporting guidelines, jointly published in Nature Medicine and the BMJ by Oxford researchers, will ensure that early studies on using Artificial Intelligence (AI) to treat real patients will give researchers the information needed to develop AI systems safely and effectively.

Major boost for Oxford’s mission to counter future pandemic threats

The Moh Family Foundation has given a substantial gift to support the work of Oxford University’s Pandemic Sciences Institute, greatly strengthening its ability to identify and counter future pandemic threats and ensure equitable access to treatments and vaccines around the world.

Three NHSBT research units launch at University of Oxford

The NIHR has awarded three new Blood and Transplant Research Units (BTRUs) to the University of Oxford.

Fourth COVID-19 vaccine dose provides stronger immunity boost than third dose, shows UK study

COVID-19 vaccines given as fourth doses in the UK offer excellent boosting immunity protection, according to the latest results from a nationwide NIHR-supported study.

COVID-19’s high blood clot risk

A recent study of patient health records found that around 1 in 100 people with COVID-19 had a venal or arterial thrombosis, with rates higher still among males, and particularly for those hospitalised.

Medical Sciences Division receives REF 2021 results

Today the UK Funding Bodies have published the outcomes of the recent national research assessment exercise, the Research Excellence Framework (REF) 2021. REF is the UK-wide assessment of research in universities, and provides an expert evaluation of the quality of the research outputs, impact and environment at subject level in each university.