Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Decoding the pharmacological goldmine in tick saliva.

None

A new study led by Radcliffe Department of Medicine, Professor Shoumo Bhattacharya, has decoded the structure of unique proteins found in tick saliva and created new ones not found in nature, paving the way for a new generation of ‘Swiss-army knife’ anti-inflammatory drugs, with customised extensions to block different inflammatory pathways.  

Previous research by Professor Shoumo Bhattacharya underlines that tick saliva can be a pharmacological gold mine, potentially yielding many new drugs which could treat disorders ranging from cardiovascular diseases and stroke to arthritis. This previous work identified a group of tick saliva proteins called evasins, which bind to and neutralise chemokines, a group of chemicals key to causing inflammation in the body.

Now the researchers have worked out the structural trick that enables tick evasins to block a complex pathway that has multiple routes to the same response. What’s more, they can now manipulate this structure to make new, custom-made proteins based on tick evasins.

Read more (Radcliffe Department of Medicine website)

Also featured in the Oxford Science Blog (University of Oxford website)

Similar stories

Major grant to strengthen research and benefit patients

Oxford University Hospitals (OUH) has made a grant of £11.5 million to the University of Oxford, which the University will match with other funding, to allow the development of major clinical research facilities which have the potential to support the introduction of innovative and ground-breaking treatments for patients.

Dr Lennard Lee awarded ACP McElwain Prize for contributions to medical oncology

Dr Lee (Department of Oncology) received the award to acknowledge his contributions during the COVID-19 pandemic, through the establishment of the UK Coronavirus Cancer Monitoring Project.

Oxford joins forces with 11 universities to launch social impact investment fund

The University of Oxford has joined forces with 11 leading universities to create Impact 12, an impact investment fund to support mission-led university ventures.

Ivermectin to be investigated as a possible treatment for COVID-19 in the PRINCIPLE trial

From today, ivermectin is being investigated in the UK as part of the Platform Randomised Trial of Treatments in the Community for Epidemic and Pandemic Illnesses (PRINCIPLE), the world’s largest clinical trial of possible COVID-19 treatments for recovery at home and in other non-hospital settings.

Potential for radiotherapy and VTP multimodality therapy for prostate cancer

A recent collaborative study from the University of Oxford has investigated the potential benefit of a combined therapy approach to prostate cancer treatment, using radiotherapy and vascular targeted photodynamic therapy (VTP), which could lead to first-in-man early phase clinical trials.

Latest data on immune response to COVID-19 reinforces need for vaccination, says Oxford-led study

A new study led by the University of Oxford has found that previous infection, whether symptomatic or asymptomatic, does not necessarily protect you long-term from COVID-19, particularly against new Variants of Concern.