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The findings, based on a Phase 1 clinical trial involving 75 healthy subjects, were published in the Journal of the American Medical Association (JAMA).
The study was led by the Oxford Vaccine Group at the University of Oxford. It tested the prime-boost Ebola vaccine regimen being developed by Janssen Vaccines & Prevention B.V. that is based on Janssen’s AdVac technology and MVA-BN technology from Bavarian Nordic A/S. Healthy volunteers were given one vaccine dose to prime their immune system, and the alternative vaccine to boost their immune response. Additional Phase 1, 2 and 3 studies are ongoing to build on these findings.