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A new study has revealed the sequence of key events in an important DNA damage pathway that is disrupted in patients with the cancer-prone Fanconi anaemia disorder.

Cryo-EM structure of a protein complex that plays a key role in the FA DNA repair pathway

The work on the Fanconi anaemia (FA) DNA repair pathway, from the labs of Dr. Martin Cohn in the Department of Biochemistry and Dr. Catherine Vénien-Bryan at the Pierre and Marie Curie University in Paris, has been published in Nature Communications. It explains how mutations in a crucial protein in the FA pathway disrupt the repair process, leading to devastating consequences for patients with the disorder.

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