NNRCO will be composed of multiple research departments, as well as a strategic and business operations department, led by Suzie Markin. As of February 2018 NNRCO has several research departments established.
Department of Discovery Bioinformatics
Led by Dr. Jan Nygaard Jensen, this department aims to go beyond data analysis services to direct and drive Type 2 diabetes target discovery using multiple bioinformatics approaches. The goal is to closely link wet lab experimental findings to provide a feedback loop of result prioritization and hypothesis generation. Our bioinformatic work will be anchored in strong biology, target networks and the druggable genome.
DEPARTMENT OF STEM CELL ENGINEERING
Led by Dr. Nicola Beer, this department aims to discover novel secreted factors and corresponding signalling pathways which modify beta-cell function, health, and viability. It combines in vitro-differentiated human stem cell-derived models with CRISPR and other genomic targeting techniques to assay beta-cell function from a single gene up to a genome-wide scale. Understanding the genes and pathways underlying beta-cell function (and dysfunction) highlights potential targets for new Type 2 Diabetes therapeutics.
Led by Dr. Fang Zhang, this department aims to discover and validate modifiers of nutrient flux, with a focus on the relationship between fatty liver disease and insulin resistance. They do this using cellular genomics methods such as single-cell sequencing and CRISPR, both for screening and building spatiotemporal models of liver function at a cellular resolution.
HIGH THROUGHPUT IMAGING
Led by Dr. Fang Zhang, this department seeks to identify novel secreted proteins and peptides that modulate anti-diabetic in vitro based assays using robotic live-cell microscopy and other high-throughput cell physiology approaches.
Page updated 05/11/2018