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An internationally recognised centre of excellence for biomedical and clinical research and teaching
New tool aims to make bowel cancer treatments more effective
Awards and Appointments General
23 November 2022
The Leedham Lab in Nuffield Department of Medicine (NDM) has been awarded over £2M from Cancer Research UK to develop a new tool that could help guide how bowel cancer patients are treated in the future.
Doug Higgs awarded the 2023 Genetics Society Medal
Awards and Appointments General
23 November 2022
The award recognises Radcliffe Department of Medicine's Professor Higgs major contribution to our understanding of how mammalian genes are switched on and off, and using haematopoiesis as a model to understand how genes function.
First evidence drug resistant bacteria can travel from gut to lung, increasing infection risks
General Research
22 November 2022
A new Oxford University study released during World Antimicrobial Awareness Week has significant findings on how antimicrobial resistance (AMR) arises and persists. The results, published today in Nature Communications, provide the first direct evidence of AMR bacteria migrating from a patient’s gut microbiome to the lungs, increasing the risk of deadly infections.
The risk of seizures and epilepsy is higher after COVID than after the flu – new research
General Research
22 November 2022
Many adolescents game a lot without negative effects on their wellbeing
General Research
21 November 2022
A new study published by University of Oxford researchers in an open-access journal, JMIR Pediatrics and Parenting, shows that although many school-age adolescents are spending considerable time gaming, it is not having a negative impact on the wellbeing.
Oxford’s Ebola vaccine recommended for deployment against Uganda outbreak
Clinical Trials General Research
18 November 2022
A vaccine developed by the Oxford Vaccine Group’s Prof Teresa Lambe and supported in clinical trials and manufacture scale-up by researchers from the Jenner Institute (Nuffield Department of Medicine) has been recommended for inclusion in a ring vaccination trial to combat a Sudan ebolavirus outbreak in Uganda.
Notice of Litchfield Lectureships 2023-24
17 November 2022
E-cigarettes are more effective than nicotine-replacement therapy in helping smokers quit
General Research
17 November 2022
The latest Cochrane Review finds high certainty evidence that nicotine e-cigarettes are more effective than traditional nicotine-replacement therapy (NRT) in helping people quit smoking.
Researchers make miniature ‘bone marrows in a dish’ to improve anti-cancer treatments
General Research
16 November 2022
Scientists from Oxford University and the University of Birmingham have made the first bone marrow ‘organoids’ that include all the key components of human marrow. This technology allows for the screening of multiple anti-cancer drugs at the same time, as well as testing personalised treatments for individual cancer patients.
Key cause of type 2 diabetes uncovered
General Research
14 November 2022
Oxford research reveals high blood glucose reprograms the metabolism of pancreatic beta-cells in diabetes.
New study shows clinical symptoms for Alzheimer’s can be predicted in preclinical models
General Research
10 November 2022
Establishing preclinical models of Alzheimer’s that reflect in-life clinical symptoms of each individual is a critically important goal, yet so far it has not been fully realised. A new collaborative study from the University of Oxford has demonstrated that clinical vulnerability to an abnormally abundant protein in Alzheimer’s brain is in fact reflected in individual patient induced pluripotent stem cell-derived cortical neurons.
New tool could help GPs predict and prevent serious falls
General Research
8 November 2022
Researchers, led by the Nuffield Department of Primary Care Health Sciences, University of Oxford, have developed a new tool for doctors to identify patients at high risk of serious falls. The tool could have a big impact on the way older patients are managed in primary care, improving targeting of drug treatment and fall prevention strategies for high-risk individuals.
Profiling the entire cancer genome identifies new subgroups of blood cancer
General Research
7 November 2022
The University of Oxford has led the largest and most comprehensive analysis of the entire genomic landscape of the commonest type of blood cancer called chronic lymphocytic leukaemia (CLL) as part of the UK’s 100,000 Genomes Project. This work defines five genomic subgroups of CLL and associates these with clinical outcomes, and these subgroups provide a better estimation of patient prognosis than achieved by previous single gene analyses, allowing more tailored patient care.
University of Oxford study provides important insights into TB correlates of protection
General Research
7 November 2022
Researchers from the University of Oxford have today reported findings from a study that investigated whether previously identified correlates of protection associated with risk of full-blown tuberculosis (TB) disease could also be associated with risk of infection from the bacteria that causes TB - highlighting certain correlates in the process.
Therapeutic HIV vaccine with Oxford technology achieves encouraging results
General Research
4 November 2022
A phase I/IIa clinical trial that the University of Oxford collaborated on has demonstrated that a T-cell therapeutic HIV vaccine was associated with better control of the virus rebound when antiretroviral therapy (ART) was temporarily withdrawn.
Bacterial armour plating has implications for antibiotics
General Research
3 November 2022
A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armour, which has far-reaching implications for the development of antibiotics.
Pancreatic cancer could be diagnosed up to three years earlier
General Research
2 November 2022
Pancreatic cancer could be identified in patients up to three years earlier than current diagnoses, new research suggests. Weight loss and increasing blood glucose levels are early indicators of pancreatic cancer and could lead to a more timely diagnosis, helping to improve survival rates.
Obituary: Professor Sir Peter J. Morris FRS (17 April 1934 – 29 October 2022)
General
1 November 2022
It is with great sadness that we report Peter Morris’s death. Peter died peacefully of metastatic colon cancer on Saturday 29 October at the age of 88, at home in Witney, surrounded by his wife Jocelyn and members of his large family. Peter has been one of the greatest Oxford medicine figures and was the third Nuffield Professor of Surgery between 1974 and 2001.