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An internationally recognised centre of excellence for biomedical and clinical research and teaching
Harnessing immune cell therapy in cancer
General Research
1 September 2020
First in a new blog series by Cancer Research UK Oxford Centre on the ongoing work happening across Oxford, for Blood Cancer Awareness Month.
New melanoma cancer drug in development shows promise
General Research
27 August 2020
Tebentafusp is being developed as a first-of-its-kind immunotherapy drug that showed promise in clinical studies in helping the immune system fight off melanoma cancers of both the eye and skin.
Cancer care during COVID-19: lessons from The Oxford Bone Tumour and Soft Tissue Sarcoma service
Coronavirus COVID-19 General Research
26 August 2020
The impact of COVID-19 on cancer patients
Coronavirus COVID-19 General Research
25 August 2020
A study co-led by the University of Oxford and University of Birmingham, published in Lancet Oncology today by the UK Coronavirus Cancer Monitoring Project (UKCCMP), found that blood cancer patients were particularly at risk with 57% higher odds of severe disease if they contract COVID-19. This was when compared to other cancer patients, such as breast cancer, which was shown to have the lowest risk overall.
Using hydroxychloroquine with common antibiotic increases cardiovascular risk
Coronavirus COVID-19 General Research
25 August 2020
The combination of hydroxychloroquine and azithromycin has been linked to significant cardiovascular risks, including mortality, in the largest safety study ever performed comparing hydroxychloroquine treatment to hydroxychloroquine and azithromycin treatment for rheumatoid arthritis patients.
IL-22 pathway linked to poor prognosis in colon cancer
General Research
19 August 2020
Research from Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences (NDORMS) shows how IL-22 interacts with KRAS mutant tumours to promote excessive growth in colorectal cancer
Latest version of COVID-19 contact tracing app ready for testing on the Isle of Wight and Newham, London
Coronavirus COVID-19 General Research
14 August 2020
The Department of Health & Social Care announced the latest version of the contact tracing app will be tested on the Isle of Wight and with NHS volunteers from this week, and in the London Borough of Newham from next week. The app will enable you to report your symptoms and book a test directly through the app. If you test positive for COVID-19, your close proximity contacts from the last 2 weeks will be notified and advised to isolate to prevent onward spread of the virus.
Pain trajectory defines knee osteoarthritis subgroups
General Research
13 August 2020
Researchers at NDORMS have identified four subgroups of knee osteoarthritis which will improve patient treatment and drug development.
Scientists uncover the role of neuronal networks in moving between wake and sleep states
General Research
13 August 2020
Changes in the way that neurons communicate with each other affect our ability to move between sleep and wake states.
Grant towards OHDSI Global Research on COVID-19 treatments
Coronavirus COVID-19 General Research
10 August 2020
An international cohort of OHDSI collaborators obtain a grant from the COVID-19 Therapeutics Accelerator to lead an effort to compare the effectiveness of treatments, including corticosteroids such as dexamethasone, under current evaluation for COVID-19 across an international observational data network.
Hydroxychloroquine is being discarded prematurely in COVID-19 prevention
Coronavirus COVID-19 General Research
10 August 2020
Hydroxychloroquine could still prevent COVID-19 and save tens of thousands of lives around the world, say leading scientific researchers. While it doesn’t work in treatment of hospitalised patients, it could still prevent infections. However, fraudulent data, unjustified extrapolation and exaggerated safety concerns together with intense politicisation and negative publicity may stop COPCOV, the only large, global clinical trial testing hydroxychloroquine in COVID-19 prevention, from ever finding out.
BRC-OCDEM project wins European funding for citizen science metabolism project
Awards and Appointments General Research
10 August 2020
The NIHR Oxford Biomedical Research Centre (BRC) has received more than €270,000 from the European Commission as a part of a multi-nation research project to promote citizen science.
A novel strategy for using compounds as ‘anti-evolution’ drugs to combat antibiotic resistance
General Research
7 August 2020
The rise of antibiotic resistance in many pathogens has been driven by the spread of a small number of strains, suggesting that some bacteria may be genetically pre-disposed to evolving resistance. Researchers at Oxford University have tested this hypothesis by quantifying differences in evolvability between pathogen strains and by searching for ‘potentiator’ genes that accelerate the evolution of resistance. Their results are published today in Nature Communications.
PRINCIPLE and ZOE partner to widen access to trial
Coronavirus COVID-19 General Research
4 August 2020
Oxford University and the COVID Symptom Study app are joining forces to widen access to the PRINCIPLE trial of potential treatments for COVID-19.
Professor Fran Platt secures £1M funding over two years for vital Parkinson's Disease research, in collaboration with Pfizer
Awards and Appointments General Innovation Research
4 August 2020
There is an increasing body of genetic and biochemical evidence that points toward lysosomal dysfunction as a risk factor for developing age-related neurodegenerative disorders, including Parkinson’s disease (PD).
New AI test identifies COVID-19 within one hour in emergency departments
Coronavirus COVID-19 Research
30 July 2020
Infectious disease and clinical machine learning experts at the University of Oxford have developed an Artificial Intelligence test that can rapidly screen for COVID-19 in patients arriving in emergency departments, and a preprint paper has been published on its effectiveness.
3D printing for brain repair
Research
30 July 2020
An in-depth look into a collaborative Department of Physiology, Antomy and Genetics (DPAG), Chemistry and Oxford Martin School project pioneering a radical new approach in which the brain is repaired with 3D-printed neural tissues.
Researchers discover cell communication mechanism that drives cancer adaptation
Research
28 July 2020
Collaborative Cancer Research UK-funded studies from University of Oxford researchers have uncovered a new mechanism by which cancer cells adapt to the stresses they encounter as they grow and respond to therapies. This mechanism involves cells releasing small vesicles, known as exosomes.
New study enables identification of people at particular risk of rare, but serious, muscle-related side effect of statin therapy
Research
24 July 2020
Statins are prescribed to millions of people worldwide to reduce their risks of suffering heart attacks and strokes. Researchers at the Nuffield Department of Population Health, in collaboration with other researchers, have published new findings that identify a combination of factors that put some patients at higher risk of myopathy, which is a rare side-effect of statin therapy characterised by muscle pain or weakness in combination with high blood levels of creatine kinase, a marker of muscle damage.