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An internationally recognised centre of excellence for biomedical and clinical research and teaching
World’s largest clinical trial for COVID-19 treatments expands internationally
Clinical Trials Coronavirus COVID-19 General
18 February 2021
The Randomised Evaluation of COVID-19 Therapy (RECOVERY) Trial, the world’s largest clinical trial for COVID-19 treatments, has now expanded internationally with Indonesia and Nepal among the first countries to join. The first patients have been recruited to RECOVERY International.
World Health Organization lists Oxford coronavirus vaccine for emergency use
Clinical Trials Coronavirus COVID-19 General
15 February 2021
The Oxford / AstraZeneca vaccine has today been granted Emergency Use Listing (EUL) by the World Health Organization (WHO) for active immunisation to prevent COVID-19 in individuals 18 years of age and older, including those over 65.
Oxford University extends COVID-19 vaccine study to children
Clinical Trials Coronavirus COVID-19 General
12 February 2021
The University of Oxford, together with three partner sites in London, Southampton and Bristol, is to launch the first study to assess the safety and immune responses in children and young adults of the ChAdOx1 nCoV-19 coronavirus vaccine.
Drug trial that could improve respiratory recovery from COVID-19 now underway
Clinical Trials Coronavirus COVID-19 General
10 February 2021
A clinical trial has commenced this week to test whether a drug called Almitrine can help people who are seriously ill with COVID-19 to recover from the disease.
ChAdOx1 nCov-19 provides minimal protection against mild-moderate COVID-19 infection from B.1.351 coronavirus variant in young South African adults
Clinical Trials Coronavirus COVID-19 General
8 February 2021
In an analysis, submitted as a pre-print prior to peer-review publication, a two-dose regimen of the ChAdOx1 nCoV-19 vaccine provides minimal protection against mild-moderate COVID-19 infection from the B.1.351 coronavirus variant first identified in South Africa.
Oxford vaccine effective against major B.1.1.7 ‘Kent’ coronavirus strain circulating in the UK
Clinical Trials Coronavirus COVID-19 General
5 February 2021
A preprint of ongoing work to assess effectiveness of Oxford’s ChAdOx1 coronavirus vaccine shows that the existing vaccine has similar efficacy against the B.1.1.7 ‘Kent’ coronavirus strain currently circulating in the UK to previously circulating variants.
Oxford leads first trial investigating dosing with alternating vaccines
Clinical Trials Coronavirus COVID-19 General
4 February 2021
The University of Oxford is to lead the first trial to explore alternating different COVID-19 vaccines, to explore the potential for flexibility in delivery and look for clues as to how to increase the breadth of protection against new virus strains.
Oxford coronavirus vaccine shows sustained protection of 76% during the 3-month interval until the second dose
Clinical Trials Coronavirus COVID-19 General Research
2 February 2021
Researchers at the University of Oxford have today published in Preprints with The Lancet an analysis of further data from the ongoing trials of the vaccine. In this, they reveal that the vaccine efficacy is higher at longer prime-boost intervals, and that a single dose of the vaccine is 76% effective from 22- to up to 90-days post vaccination.
RECOVERY trial closes recruitment to convalescent plasma treatment for patients hospitalised with COVID-19
Clinical Trials Coronavirus COVID-19 General Research
18 January 2021
The RECOVERY trial was established as a randomised clinical trial to test a range of potential treatments for COVID-19.
Oxford University welcomes UK regulatory emergency use authorisation of coronavirus vaccine
Clinical Trials Coronavirus COVID-19 General Research
30 December 2020
The University of Oxford welcomes the news that the UK Government has today accepted the recommendation from the Medicines and Healthcare products Regulatory Agency (MHRA) to authorise the emergency use of the ChAdOx1 nCoV-19 coronavirus vaccine in the UK.
Oxford vaccine stimulates broad antibody and T cell functions
Clinical Trials Coronavirus COVID-19 Research
17 December 2020
Today, researchers from the University of Oxford have published further data from the Phase I/II clinical trials of the ChAdOx1 nCoV-19 coronavirus vaccine, evidencing the decision to move to a two-dose regimen in ongoing phase III trials, and how ChAdOx1 nCov-19 induces broad antibody and T cell functions.
First peer-reviewed results of phase 3 human trials of Oxford coronavirus vaccine demonstrate efficacy
Clinical Trials Coronavirus COVID-19 General Research
8 December 2020
Today University of Oxford and AstraZeneca researchers present a pooled analysis of Phase 3 trials of a vaccine against SARS-CoV-2 across two different dose regimens, resulting in an average efficacy of 70.4%.
Oxford coronavirus vaccine produces strong immune response in older adults
Clinical Trials Coronavirus COVID-19 General Research
19 November 2020
The ChAdOx1 nCov-2019 coronavirus vaccine, developed by teams at the University of Oxford, has been shown to trigger a robust immune response in healthy adults aged 56-69 and those over 70 years of age.
Interferon-b trial shows positive results
Clinical Trials Coronavirus COVID-19 General Research
16 November 2020
A trial of a new inhaled antiviral drug for COVID-19 has shown positive results and the drug is now moving into a larger international phase 3 trial of hospitalised patients.
Trials of Oxford coronavirus vaccine begin in Kenya
Clinical Trials Coronavirus COVID-19 Research
2 November 2020
Kenya has joined the global efforts in search of an effective vaccine for COVID-19 with the start of a trial evaluating the ChAdOx1 nCoV-2019 Oxford coronavirus vaccine.
Global clinical trials of COVID-19 vaccine resume
Clinical Trials Coronavirus COVID-19 Research
23 October 2020
The Food and Drug Administration (FDA) has today authorised a restart of clinical trials of the ChAdOx1 nCov-2019 Oxford coronavirus vaccine in the USA following the trials restarting in the UK, Brazil, South Africa and Japan.
Oxford COVID-19 vaccine follows its programmed genetic instructions, independent analysis finds
Clinical Trials Coronavirus COVID-19 Research
22 October 2020
A team at Bristol University has used recently developed techniques to validate that the vaccine accurately follows the genetic instructions programmed into it by the Oxford team.
Britain’s most influential Hindu temple spreads awareness of the PRINCIPLE trial among Indian Community
Clinical Trials Coronavirus COVID-19 Research
21 October 2020
Europe’s BAPS Swaminarayan Sanstha is supporting their community during the coronavirus pandemic by spreading awareness of the PRINCIPLE trial of Covid-19 treatments.
New trial to treat Covid-19 in care homes using anti-TNF drug begins
Clinical Trials Coronavirus COVID-19 Research
30 September 2020
Researchers at the University of Oxford are starting a new study to explore the effectiveness of the anti-tumour necrosis factor (anti-TNF) drug adalimumab as a treatment for patients with COVID-19 in the community, especially care homes.
Coronavirus: the road to vaccine roll-out is always bumpy, as 20th-century pandemics show
Clinical Trials Coronavirus COVID-19 General
23 September 2020