Cardiovascular responses to hypoxia and hypercapnia
Keith Dorrington graduated in Engineering Science in the University of Oxford in 1974. He researched the thermodynamic properties and molecular structure of the connective tissue protein elastin for a DPhil in 1977, and took the degrees of BM BCh in 1982. His work on extracorporeal gas exchange provided early evidence for benefit of the therapy in experimental respiratory failure and was the basis for his text Anaesthetic & Extracorporeal Gas Transfer (OUP, 1989) and the degree of DM. He is a Fellow of the Royal College of Anaesthetists and Honorary Consultant to the Oxford Radcliffe Hospital. He is Lecturer in Physiology and Fellow of University College, Oxford.
Keith Dorrington’s research interests include the regulation by respiratory gases of the pulmonary circulation, the role of the autonomic nervous system in modulating acclimatization to hypoxia, and the application of control theory to the understanding of the regulation of complex physiological systems (regulomics). Of particular current relevance is the question to what extent hypoxia-driven gene expression leads to a restructuring of the cardiovascular and respiratory systems as acclimatization proceeds over periods of time ranging from hours to weeks. Other interests include the dehumanization of modern medical care.
Further information can be found at Dorrington Research