Aspects of the pathogenicity of African trypanosomes and inherited ciliary diseases of humans.
Keith Gull's research laboratory is part of the Molecular Microbiology grouping in the Sir William Dunn School of Pathology. The lab works on integrated aspects of biology from both an evolutionary and health perspective with the main focus of the work being the protozoan parasites Trypanosoma brucei - the causative agent of human sleeping sickness and Leishmania species which cause a variety of Leishmanial infections. Among the current research interests of the lab are: the microtubule cytoskeleton, the flagellum and cell morphogenesis, cell cycle and cytokinesis processes, segregation of the trypanosome genome, mitotic spindle / kinetochore organization, interphase nuclear structures and nuclear architecture.
There is much overlap between components, structure and function of the trypanosome flagellum and the cilia and flagella of human. We therefore have research interests in the flagella/cilia of mammalian cells in health and disease.
• The trypanosome microtubule cytoskeleton, flagellum and cell morphogenesis
• The genome of African trypanosomes
• The flagellum/cilium of mammalian cells in health and disease
• Parasite: macrophage interactions