Haematology

Scientist working in Oxford have made major contributions to this field. Robert Gwynne Macfarlane was instrumental in identifying the clotting cascade. George Brownlee first cloned the Factor IX gene, leading to the production of recombinant Factor IX now used to treat patients with haemophilia B. Sir David Weatherall pioneered research into the inherited basis of blood disorders, particularly thalassaemia, culminated in a prestigious Lasker Award in 2010.

Research in haematology is concentrated in the MRC Molecular Haematology Unit housed in the Weatherall Institute of Molecular Medicine and the Nuffield Department of Clinical Laboratory Sciences. Areas of strength include the mechanisms regulating globin gene expression, leukemia and lymphomas.

Related links

Supervisors in Haematology

Alison Banham

Therapeutic antibodies for cancer therapy. Transcriptional deregulation in lymphomagenesis.

Marella de Bruijn

Hematopoietic stem cell generation during embryonic development

Claire Edwards

Research interests are focused upon the pathogenesis of cancer-induced bone disease, including the contributions of the host bone marrow microenvironment and the role of obesity, adipocytes and adipokines

Panagis Filippakopoulos

Protein Science and Structural Biology

Richard Gibbons

Chromatin remodelling factors in human disease

Opher Gileadi

Biotechnology and Genome Integrity

Colin, R Goding

Cancer, development and stem cell biology

Doug Higgs

The regulation of gene expression during erythropoiesis

William James

HIV-Macrophage interactions and stem cell technology

Rob Klose

Epigenetic regulation of chromatin function

Stephan Knapp

Phosphorylation Dependent Signalling Biology Group

Skirmantas Kriaucionis

Epigenetic Mechanisms

Brian Marsden

Protein Science and Structural Biology

Adam Mead

Leukaemia Stem Cell Biology

Tom Milne

Epigenetic control of gene expression in leukemia and haematopoiesis

Roger Patient

Programming blood and the cardiovascular system

Patrick Pollard

Cell and Molecular Biology

Catherine Porcher

Transcriptional control of haemopoietic stem cell specification and differentiation

David Roberts

Erythropoiesis / Regulatory T cells in Bone Marrow Transplantation / Malaria Pathogenesis

Angela Russell

Medicinal Chemistry

Anna Schuh

Genetics and Genomics

Katja Simon

Cell death and Autophagy in the Immune and Hematopoietic System

Alain R Townsend

Iron Metabolism and Immunology

Paresh Vyas

Normal and Leukaemic stem/progenitor cell biology

Suzanne Watt

Improving bone marrow transplants- through better engraftment / Stem/progenitor cell expansion and reprogramming / Revascularising tissues for tissue repair

Thomas N Williams

Host Genetics: Haemoglobinopathies and Infectious Disease

Refine by sub-theme

Show all
Haematology
Anaemias
Lineage Commitment and Differentiation in haematopoiesis
Epigenetics in haematopoiesis
Gene Regulation in haematopoiesis
Leukaemia and Lymphoma
Haematopoietic stem cells