Diabetes, Endocrinology and Metabolism

Crosstalk between adipose tissue and vascular/myocardial redox state in humans: Pharmacological interventions

Ion channels, diabetes and obesity

Health Evaluative Methodologies

Peripheral chemoreceptors and the effects of hypoxia, acidosis & ischemia on neuronal function

Nitric oxide/redox signalling in health and disease (e.g., myocardial ischaemia, diabetes, heart failure and atrial fibrillation)

Nitric oxide and redox signalling in cardiovascular disease

Glucocorticoids, Annexin 1 and the Neuroendocrine–Immune Interface

Determinations of cyclic ADP-ribose and NAADP levels. Endogenous synthesis and metabolism of NAADP. Signal transduction pathway underlying NAADP production. Spatial and temporal control of calcium increases by NAADP. Physiological roles of NAADP and lysosome-related calcium-storing organelles. Development of caged and cellpermeant messengers.

Metabolic control of gene expression in heart failure and in the diabetic heart

Cell and Molecular Biology

Much of the research that Professor Farmer has recently led or collaborated on aims to improve the effectiveness of tests and treatments for people with diabetes, for example the use of telehealth to support self-management in diabetes, although recent trials also include evaluation of telehealth support for people with COPD, and use of text messaging to support treatment adherence in hypertension.

Protein Science and Structural Biology

Cell biology of signalling in development and disease

Isolated organ perfusion and preservation Clinical trials of novel Immunosuppression

Regulation of intracellular channels Calcium-mobilising second messengers, Cyclic ADP-ribose and NAADP as second messengers, Organization of intracellular Ca2+ signals, Molecular characterization of novel calcium release channels, Molecular signaling at fertilization, Stimulus-secretion coupling in exocrine and endocrine pancreas Excitation-contraction coupling in striated and smooth muscle Role of acidic calcium stores in calcium signaling

The genetics and functional biology of Type-2 diabetes & related traits

Cellular nutrient sensing in cancer and diabetes

Genetics and Genomics

Integrative Physiology (Systems Biology)

Diabetes Trials Unit (DTU)

My research addresses the practical challenges of delivering evidence based primary health care in the modern NHS environment. I am particularly interested in the potential of routinely collected data to influence practice at the point of care, through innovative tools including software interventions.

APSPU – The Academic Paediatric Surgery Unit undertakes research ranging from basic laboratory science to evidence-based clinical studies. The principal area of research relates to the endocrine pancreas, and in particular the field of pancreatic islet transplantation for juvenile-onset diabetes; OXCIT – Oxford Consortium for Islet Transplantation, is a multi-disciplinary team that aims to achieve insulin independence in patients with diabetes by transplanting pancreatic islets of Langerhans.

Oxford Laboratory for Integrative Physiology (Oxlip)

Cardiovascular Imaging and Early Development of Cardiovascular Disease

The genetics of obesity

The Genetics of Type-2 Diabetes & Related Traits

Genetic and Genomic Epidemiology Unit

Genetics of Type 2 Diabetes & Monogenic Diabetes

Molecular basis of egg activation. Role of phospholipase C enzymes in sperm. Calcium signalling and early embryogenesis. In vivo gene transfer into the testis and sperm. Identification and characterisation of the NAADP receptor. Molecular components of calcium signalling in sea urchin gametes

Glycosphingolipids in health and disease.

Clinical, translational & experimental research in organ donation and transplantation and focus on mechanisms of injury & repair relevant to enhance donor organ quality, reduce ischaemia-reperfusion injury, improve preservation and allow regeneration after transplantation to increase allograft function and survival.

Cell and Molecular Biology

Human Physiology: Effects of hypoxia and exercise on respiratory, cardiovascular and metabolic function

Diabetes, Insulin secretion

Alzheimer’s disease: diagnosis, aetiology and prevention. Control of Obesity.

Molecular basis of endocrine and renal tubular disorders

Development and Application of Cardiac Magnetic Resonance Imaging and Spectroscopy

Intracellular pH in heart: regulation and function

Human disease and proteins.

Regulation of Cell Growth, Migration and Metabolism in Normal and Cancer Cells

Transplant rejection and tolerance