Genes, Genetics, Epigenetics and Genomics

Oxford has been at the forefront of the new information age in biology, playing a leading role in the public analysis of both the human and mouse genomes and in the HapMap and Wellcome Trust Case Control Consortium’s investigations into genetic variation in health and disease.

Increasingly, the rising tide of biological data challenges biologists to integrate and interpret  diverse sources of information in order to understand the role of genetic and epigenetic variation. From developmental disorders to degenerative disease, our confidence to embrace these new genomic technologies maintains our research at the cutting-edge of medical science.

Supervisors in this area are based in the Departmental of Physiology, Anatomy and Genetics, the Nuffield Department of Clinical Medicine, the Sir William Dunn School of Pathology, and the Department of Biochemistry. Institutes and Units include the Wellcome Trust Centre for Human Genetics, the Weatherall Institute of Molecular Medicine, and the MRC Functional Genomics and Molecular Haematology Units. Some supervisors not listed here are based in the Department of Statistics.

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Supervisors in Genes, Genetics, Epigenetics and Genomics

Esther Becker

Molecular mechanisms governing cerebellar development and disease

Jo Begbie

Development of Sensory Ganglia

Mahmood Bhutta

Genetics and therapy of otitis media

Liz Bikoff

Epigenetic regulators of embryonic development

Neil Brockdorff

Developmental Epigenetics

Veronica Buckle

Cell and Molecular Biology

Phil Burnet

The molecular neurobiology of D-amino acids and their relevance to schizophrenia

Martin Burton

Genetics and Therapy of Otitis Media

Simon Butt

Interneuron development and function

Martin Cohn

Maintenance of genomic stability and DNA repair in humans

Lynne Cox

Replicative senescence: towards an understanding of cellular ageing

Ben Davies

Transgenic Technology Research Group

Kay E Davies

Molecular analysis of neurological disorders

Marella de Bruijn

Hematopoietic stem cell generation during embryonic development

Peter Donnelly

Statistical Genetics

Fumiko Esashi

Regulation of DNA repair by cell cycle regulators

Matthew Freeman

Cell biology of signalling in development and disease

Tudor Fulga

Non-coding RNAs in development and disease

Andre Furger

Control of gene expression in eukaryotes

Richard Gibbons

Chromatin remodelling factors in human disease

Anna L Gloyn

The genetics and functional biology of Type-2 diabetes & related traits

Eva Gluenz

Cell biology of Leishmania; role of the flagellum in host-parasite interactions

Deborah Goberdhan

Cellular nutrient sensing in cancer and diabetes

Stephen Goodwin

Genes, Circuits and Behaviour

Stephen Gough

Genetics and Genomics

Natalia Gromak

Regulation of RNA metabolism in health and disease

Keith Gull

Aspects of the pathogenicity of African trypanosomes and inherited ciliary diseases of humans.

Doug Higgs

The regulation of gene expression during erythropoiesis

Jonathan Hodgkin

Genetics of nematode immunity and development

Georg Hollander

The Immunobiology of the Thymus and the T cell System

Fredrik Karpe

Oxford Laboratory for Integrative Physiology (Oxlip)

Rob Klose

Epigenetic regulation of chromatin function

Dominic Kwiatkowski

Genomics and Global Health

Simon Leedham

Homeostatic cell-signaling pathways that control intestinal stem cells and the dysregulation of these pathways in carcinogenesis.

Kerstin Luhn

Immune regulation and innate immune responses in Dengue and other viral infections

Mark McCarthy

The Genetics of Type-2 Diabetes & Related Traits

Jane Mellor

Chromatin remodeling and gene regulation in simple eukaryotes

Tom Milne

Epigenetic control of gene expression in leukemia and haematopoiesis

Shona Murphy

Regulation of expression of human genes.

Kim Nasmyth

Chromosome Segregation During Mitosis and Meiosis

Chris I Newbold

Molecular Parasitology, Malaria

Chris Norbury

Studying the involvement of post-transcriptional regulation of gene expression in cancer cell biology

Katharine Owen

Genetics of Type 2 Diabetes & Monogenic Diabetes

Anant Parekh

Intracellular calcium signalling

John Parrington

Molecular basis of egg activation. Role of phospholipase C enzymes in sperm. Calcium signalling and early embryogenesis. In vivo gene transfer into the testis and sperm. Identification and characterisation of the NAADP receptor. Molecular components of calcium signalling in sea urchin gametes

Roger Patient

Programming blood and the cardiovascular system

Chris Ponting

Evolution of genes and genomes

Catherine Porcher

Transcriptional control of haemopoietic stem cell specification and differentiation

Joanna Poulton

Mitichondrial Genetics

Nicholas Proudfoot

Interconnecting transcription and RNA processing in eukaryotes

Jan Rehwinkel

Nucleic Acid Sensing by Innate Immune Receptors

Peter Robbins

Human Physiology: Effects of hypoxia and exercise on respiratory, cardiovascular and metabolic function

Liz Robertson

Cell interactions underlying mammalian development and immune recognition.

Tatjana Sauka-Spengler

Genetics and Genomics

A David Smith

Alzheimer’s disease: diagnosis, aetiology and prevention. Control of Obesity.

Kevin Talbot

Motor Neuron Diseases

Rajesh V Thakker

Molecular basis of endocrine and renal tubular disorders

Ian Tomlinson

Molecular and Population Genetics of Cancer

Irina Udalova

Genomic and epigenetic control of inflammation: identification of key master regulators

Lidia Vasilieva

Post-transcriptional regulation of gene expression in eukaryotes

Scott Waddell

Neural Mechanisms of Memory, Motivation and Behavioural Control

Caleb Webber

Neurological Disease Genomics

Matthew Whitby

Genetic recombination and DNA repair in eukaryotes

Andrew Wilkie

Skulls, limbs, and sperm: common themes in malformation

Matthew Wood

Gene therapy for degenerative disorders of the nervous system and muscle

Alison Woollard

Molecular mechanisms controlling cell fate determination and cell proliferation during C. elegans development

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Genes, Genetics, Epigenetics and Genomics