Cancer

Oxford has made major contributions to our understanding of cancer. The link between smoking and cancer was demonstrated here by Sir Richard Doll and the existence of tumour suppressor genes was demonstrated in cell fusion experiments by Sir Henry Harris. Following substantial investment in the past decade, and the relocation of the Ludwig Institute of Cancer Research from London in 2007, Oxford now has one of the highest concentrations of world-class cancer research in the world.  Much of the expansion has occurred at the Old Road Campus, conveniently located near the new NHS Oxford Cancer Centre.

Oxford is rated particularly highly in cancer epidemiology, genome integrity, radiation biology and translational research. There is basic and translational research into environmental risk factors and the molecular genetic basis of cancer, including oncogenes, tumour suppressor genes, genome integrity and repair. The tumour environment has become a major new area of research, and Oxford leads the way in understanding the role of hypoxia, angiogenesis, growth factors, metastasis and stem cells in cancer. Oxford has invested in early phase clinical trials and developing personalized medicine in partnership with Cancer Research UK, and develops radiation treatments in partnership with the Gray Institute for Radiation, Oncology and Biology.

Departments in which cancer research is a major theme include the Departments of Oncology and Biochemistry, the Sir William Dunn School of Pathology and the Nuffield Departments of: Clinical Medicine; Clinical Laboratory Sciences; Surgical Sciences; and Orthopaedics, Rheumatology and Musculoskeletal Sciences.

Cancer research is also performed in the Weatherall Institute of Molecular Medicine and at the Wellcome Trust Centre for Human Genetics.

Some supervisors working in this theme are not included here as they are not in the Medical Sciences Division. They can be found in the Departments of Chemistry, Engineering, Physics and Zoology

The Oxford Cancer Research Centre awards a number of generous 4 year DPhil studentships every year, funded by Cancer Research UK. All applicants applying on a cancer-related project, across all departments, will automatically be considered for these studentships and can explicitly request that they be considered when they make their application.  These prestigious studentships will be awarded to the highest calibre applicants from across all relevant Departments.


The Centre also awards 2 Clinical Research Fellowships each year, available for clinicians wishing to undertake a DPhil and provides MSc bursaries for clinicians and allied health professionals to undertake a MSc at Oxford.

Structured DPhil Programmes

MSc Taught Programmes

Other relevant Progammes

Related links

Supervisors in Cancer

Ahmed Ahmed

Ovarian Cancer

Colin N Baigent

Clinical trials, Meta-analysis, Epidemiology and Cardiovascular disease

Alison Banham

Therapeutic antibodies for cancer therapy. Transcriptional deregulation in lymphomagenesis.

Francis Barr

Spatial and temporal control of mitosis and cytokinesisand control of membrane trafficking by Rab GTPases

Valerie Beral

Cancer Epidemiology and Women's Health

Walter Bodmer

Cancer & Immunogenetics Laboratory

Gareth Bond

Oxford Ludwig Institute

Jacqueline Boultwood

Molecular pathogenesis of the myelodysplastic syndromes (MDS), including the 5q- syndrome

Chas Bountra

Structure, function and drug target discovery

Neil Brockdorff

Developmental Epigenetics

Thomas Brunner

The influence of desmoplasia on tumour response after radiation and studying cell signalling in the tumour and normal cell compartments before and after radiation to identify potential targets.

Vincenzo Cerundolo

Vaccination, cancer immunology and NKT cell function

Zhengming Chen

Kadoorie Biobank Study

John Christianson

ER-associated degradation and regulation of the secretory pathway

Martin Cohn

Maintenance of genomic stability and DNA repair in humans

Lynne Cox

Replicative senescence: towards an understanding of cellular ageing

David Cranston

The High Intensity Focussed Ultrasound group was set in 2002 and has close international links with Chongqing in China. The group is currently investigating the treatment of solid tumours at the Churchill Hospital and has close research links with Professor Gail ter Haar, scientific director of the unit and Dr Constantin Coussios in Biomedical engineering.

Francesca Crowe

Clinical Epidemiology

Sarah C Darby

Cancer Epidemiology

Sarah De Val

Angiogenesis Group

Grigory Dianov

Our long-term goal is to study the proteins and mechanisms involved in the coordination and regulation of base excision repair, to unravel their role in the repair of radiation induced DNA damage and to examine the relationship to human diseases, such as cancer.

Tao Dong

Anti-viral T cell response

Omer Dushek

Systems Biology of Lymphocyte Signaling

Claire Edwards

Research interests are focused upon the pathogenesis of cancer-induced bone disease, including the contributions of the host bone marrow microenvironment and the role of obesity, adipocytes and adipokines

Fumiko Esashi

Regulation of DNA repair by cell cycle regulators

Paul Fairchild

Addressing the immunological barriers to stem cell therapies.

Stephan Feller

The Biological Systems Architecture Group

Panagis Filippakopoulos

Protein Science and Structural Biology

Matthew Freeman

Cell biology of signalling in development and disease

Tudor Fulga

Non-coding RNAs in development and disease

Andre Furger

Control of gene expression in eukaryotes

Kevin Gatter

Angiogenesis, non angiogenesis, molecular analysis, gene expression profile, lung cancer

Maike Glitsch

Transduction cascades involved in cerebellar signalling in health and disease, transduction pathways (G-protein coupled receptors and ion channels)

Deborah Goberdhan

Cellular nutrient sensing in cancer and diabetes

Colin, R Goding

Cancer, development and stem cell biology

Ulrike Gruneberg

Mechanisms regulating mitotic progression

Freddie Hamdy

Management of prostate/ bladder cancer; basic/translational research into molecular mechanisms of progression; cancer-induced bone disease; biomarker research

Ester Hammond

The focus of my lab is the biological consequences of hypoxia initiating a DNA damage response in the absence of DNA damage.

Penny Handford

cbEGF containing proteins in health and disease

Bass Hassan

Molecular and functional aspects of tumour growth, and how the molecules that control growth can be targeted for application to human cancer therapy.

Thomas Helleday

Goals are to exploit tumour defects for targeted treatment of cancer.

Mark Hill

Investigate how differences in the biophysical features of radiation tracks determine biological response to evaluate impact on human health and facilitate radiation work across the Institute.

Mark Howarth

Bionanotechnology and its application to Cancer

Tim Humphrey

Understanding how genome stability is maintained in response to DNA double-strand breaks.

Yoshifumi Itoh

The mechanism of cell invasion process in tissue degenerative diseases

David G Jackson

Lymphatics and cell trafficking

E. Yvonne Jones

Receptor Structure Research Group

Fredrik Karpe

Oxford Laboratory for Integrative Physiology (Oxlip)

Benedikt M Kessler

Ubiquitin Proteolysis Group

Tim Key

Cancer Epidemiology Unit

Anne Kiltie

The focus of my lab is the investigation of DNA damage signalling and DNA repair as they relate to the aetiology of bladder cancer and its response to radiotherapy and combined modality treatments.

Rob Klose

Epigenetic regulation of chromatin function

Hee (Anthony) Kong

Human Epidermal Growth Factor Receptor

Skirmantas Kriaucionis

Epigenetic Mechanisms

Nick La Thangue

Cancer Biology

Nick Lakin

Detection, Signalling and Repair of DNA Damage

Martin J Landray

Clinical Trial Service Unit

Bethan Lang

Autoantibodies in neurological diseases

Simon Leedham

Homeostatic cell-signaling pathways that control intestinal stem cells and the dysregulation of these pathways in carcinogenesis.

Ji-Long Liu

Intracellular compartmentation in Drosophila

Xin Lu

Tumour Supression

Valentine Macaulay

IGF Group

Louis Mahadevan

Kinase cascades targeted to transcription factors and nucleosomal proteins involved in gene induction

Sue Mallett

My research is to design and analyse diagnostic and prognostic studies, including ongoing clinical trials and methodological work.

Erika J Mancini

Chromatin Remodeling and Transcriptional Regulation

Brian Marsden

Protein Science and Structural Biology

Peter McHugh

DNA damage and repair group

Gillies McKenna

Molecular Resistance to Treatments

Adam Mead

Leukaemia Stem Cell Biology

Tom Milne

Epigenetic control of gene expression in leukemia and haematopoiesis

David R Mole

Oxygen Sensing Group

Michael Murphy

Childhood Cancer Research

Ruth Muschel

Research group interested in the mechanisms underlying the development of metastasis.

Kim Nasmyth

Chromosome Segregation During Mitosis and Meiosis

Chris Norbury

Studying the involvement of post-transcriptional regulation of gene expression in cancer cell biology

Bela Novak

Dynamics of molecular regulatory networks

Eric O'Neill

The main areas of interest in our lab are cell signalling and stem cells and cancer stem-like cells.

Peter O'Neill

Focuses on how clusters of DNA damage, formed by ionising radiation, detrimentally interfer with the maintenance of genome stability.

James Parker

Structural and molecular biology of RNA silencing

Roger Patient

Programming blood and the cardiovascular system

Catherine Pears

The role of kinases in the choice of cell fate

Francesco Pezzella

Angiogenesis, non angiogenesis, molecular analysis, gene expression profile, lung cancer

Patrick Pollard

Cell and Molecular Biology

Nicholas Proudfoot

Interconnecting transcription and RNA processing in eukaryotes

Jordan Raff

Centrioles and centrosome function.

Peter J Ratcliffe

Hypoxia Biology Group

Peter Rose

Cancer survivors in primary care

Angela Russell

Medicinal Chemistry

Andy Ryan

Lung cancer translational science

Tatjana Sauka-Spengler

Genetics and Genomics

Len Seymour

Medicinal Virology

Ricky Sharma

Translation of biochemical knowledge of DNA adducts and excision repair to the prevention and treatment of cancer.

Nicola Sibson

Multimodal imaging of brain metastasis

Christian Siebold

Hedgehog Signalling Group

Alan Storey

Cell Death Regulation Group

Madalena Tarsounas

How homologous recombination (HR), the major error-free pathway for DNA repair in mammalian cells, regulates telomeres and acts to prevent genomic instability, the underlying mechanism of many cancers.

Rajesh V Thakker

Molecular basis of endocrine and renal tubular disorders

Ian Tomlinson

Molecular and Population Genetics of Cancer

Ruth Travis

Clinical Epidemiology

Ioannis Vakonakis

Structural studies of large assemblies in malaria cytoadherence and centriole duplication

Katherine Vallis

Development of novel anti-cancer radiopharmaceuticals.

Richard Vaughan-Jones

Intracellular pH in heart: regulation and function

David Vaux

Human disease and proteins.

Boris Vojnovic

Development of instrumentation to address specific biological hypotheses, primarily involving imaging and image processing.

Paresh Vyas

Normal and Leukaemic stem/progenitor cell biology

Suzanne Watt

Improving bone marrow transplants- through better engraftment / Stem/progenitor cell expansion and reprogramming / Revascularising tissues for tissue repair

Anthony Watts

Resolving structural details of membrane peptides and proteins at high resolution

Matthew Whitby

Genetic recombination and DNA repair in eukaryotes

Robert Wilkins

Cellular physiology of cartilage

Clive Wilson

Regulation of Cell Growth, Migration and Metabolism in Normal and Cancer Cells

Alison Woollard

Molecular mechanisms controlling cell fate determination and cell proliferation during C. elegans development

Manuela Zaccolo

Intracellular signal transduction by cyclic nucleotides. Mechanisms, regulation, signalling networks and role in disease.

Nicole Zitzmann

Hepatitis - Development of Antiviral Strategies

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Molecular mechanisms (including DNA damage and repair)
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